تفاعل #81771

معادلة التفاعل

potassium carbonate

geranyl bromide

water

triiodophenol

→

(E)-1-(2,4,6-Triiodophenoxy)-3,7-dimethyl-2,6-octadiene

المردود 87.0%

المذيبات

dimethyl formamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   استخلاصThe ethyl acetate extract
4. 4
   ترشيحwas filtered through a short pad of silica gel
5. 5
   غسيلalumina, eluting with ethyl acetate-hexanes (1:1)
6. 6
   تركيزThe eluent was concentrated under high vacuum
7. 7
   أخرىto give the product in 87% yield as an oil

الإجراء التجريبي

A mixture of triiodophenol (10.0 g, 21.2 mmol), milled potassium carbonate (3.1 g, 22.5 mmol, 1.06 eq) and geranyl bromide (4.0 ml, 20.2 mmol) in dimethyl formamide (25 ml) was heated to 50° C. for 2 hrs and cooled. The mixture was poured into 300 ml of water and extracted with ethyl acetate. The ethyl acetate extract was filtered through a short pad of silica gel, then alumina, eluting with ethyl acetate-hexanes (1:1). The eluent was concentrated under high vacuum to give the product in 87% yield as an oil.

المصدر