تفاعل #81665
ord-3e05036fcc3340968a6d94747270326f
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
درجة الحرارة
80°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةcooled to room temperature
- 2تركيزconcentrated in vacuo to an oil
- 3أخرىPurification by flash chromatography (silica, 10% EtOAc-hexane)
الإجراء التجريبي
To 200 mg (0.51 mmol) of ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonapth-2-yl)ethynyl]benzoate (Compound 1) was added 0.13 ml (1.5 mmol) of acetic anhydride and 10 mg (0.05 mmol) of p-toluenesulfonic acid. The mixture was heated at 80° C. for 12 hours, cooled to room temperature and concentrated in vacuo to an oil. Purification by flash chromatography (silica, 10% EtOAc-hexane) yielded the title compound as a light yellow powder.