تفاعل #816640

معادلة التفاعل

5-bromo-2-chloropyrimidine

piperidin-4-ol

triethylamine

→

title product

1-(5-Bromopyrimidin-2-yl)piperidin-4-ol

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   workup.ADDITIONthe residue was diluted with 1N HCl (20 mL)
3. 3
   استخلاصextracted with EtOAc (3×15 mL)
4. 4
   تجفيفThe combined organic fractions were dried over Na2SO4
5. 5
   أخرىthe solvent was evaporated
6. 6
   أخرىThe product was recrystallized from CH2Cl2/hexanes
7. 7
   ترشيحfiltered
8. 8
   غسيلwashed with hexanes

الإجراء التجريبي

A mixture of 5-bromo-2-chloropyrimidine (5 g, 25.8 mmol), piperidin-4-ol (2.88 g, 28.4 mmol) and triethylamine (5.40 mL, 38.8 mmol) in EtOH (51.7 mL) was heated at 90° C. for 0.5 h. The solvent was evaporated, the residue was diluted with 1N HCl (20 mL) and extracted with EtOAc (3×15 mL). The combined organic fractions were dried over Na2SO4 and the solvent was evaporated. The product was recrystallized from CH2Cl2/hexanes, filtered and washed with hexanes to afford the title product.

المصدر