تفاعل #816430

معادلة التفاعل

oxalyl chloride

Oxalyl chloride

2-Butyl-4-hydroxy-5-phenylisothiazol-3(2H)-one 1,1-dioxide

DMF

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title compound

المردود 92.9%

2-Butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide

المردود 92.9%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was refluxed for 1.5 h
2. 2
   درجة الحرارةthe reaction mixture was refluxed for another 6 h
3. 3
   أخرىThe solvents were evaporated
4. 4
   أخرىthe residue was partitioned between water and DCM
5. 5
   غسيلThe combined organic layers were washed with water
6. 6
   أخرىthe two phases were separated
7. 7
   أخرىEvaporation of the organic phase

الإجراء التجريبي

2-Butyl-4-hydroxy-5-phenylisothiazol-3(2H)-one 1,1-dioxide (444 mg, 1.58 mmol) was dissolved in dry DCM (15 mL) at rt and under an atmosphere of nitrogen. Oxalyl chloride (0.15 mL, 1.73 mmol) was added dropwise and the reaction mixture was refluxed for 1.5 h. DMF (0.08 mL) was added followed by oxalyl chloride (0.15 mL, 1.73 mmol) in 2 portions and the reaction mixture was refluxed for another 6 h. The solvents were evaporated and the residue was partitioned between water and DCM. The combined organic layers were washed with water and the two phases were separated using a phase separator. Evaporation of the organic phase gave the title compound (440 mg, 88%) as a brown oil with approximately 95% purity according to 1H-NMR and was used without further purification; 1H-NMR (400 MHz, CDCl3): δ 7.96-8.00 (m, 2H), 7.53-7.62 (m, 3H), 3.74-3.80 (t, 2H), 1.78-1.87 (m, 2H), 1.39-1-50 (m, 2H), 0.98 (t, 3H); 13C-NMR (100 MHz, CDCl3): δ 156.3, 137.1, 132.7, 129.6, 129.2, 127.6, 123.7, 40.9, 30.1, 20.1, 13.7.

المصدر