تفاعل #816412

معادلة التفاعل

product

2-Iodo-3-formylaminothiophene

ethinyl trimethylsilane

→

2-(trimethylsilylethinyl)-3-formamido-thiophene

المردود 95.3%

المذيبات

DMF

triethylamine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   أخرىAfter 6 hours the solvents were removed under vacuum
3. 3
   أخرىthe residue was chromatographed on silica gel (hexane:ethyl acetate 2:1)

الإجراء التجريبي

The product from step A (37.8 g) was dissolved in a mixture of DMF (500 ml) and triethylamine (50 ml). CuI (1.4 g) and bis(triphenylphosphino)palladiumdichloride (5.2 g) were added under nitrogen and after 15 minutes ethinyl trimethylsilane (22 g) was added dropwise. After 6 hours the solvents were removed under vacuum and the residue was chromatographed on silica gel (hexane:ethyl acetate 2:1) to yield 2-(trimethylsilylethinyl)-3-formamido-thiophene (31.78 g) (m.p. 87-93° C.).

المصدر