تفاعل #816386
ord-7edc6e62b38842c4962ead419202b6d3
معادلة التفاعل
KCN
benzoyl chloride
water methylene chloride
benzo(f)chinolin
→
3-cyano-4-benzoyl-3,4-dihydrobenzo(f)chinoline
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىThe organic phase was separated
- 2غسيلwashed with water, 5% hydrochloric acid, water, 5% NaOH solution
- 3تجفيفAfter drying over magnesium sulfate
- 4أخرىthe solution was evaporated to dryness
الإجراء التجريبي
648 μl (5.58 mmol) benzoyl chloride was added to a two phase system of water/methylene chloride over a period of two hours. These two layers contain 500 mg (2.79 mmol) of benzo(f)chinolin in the methylene chloride layer and 545 mg (8.37 mmol) KCN in water. Stirring was continued for 6 hours. The organic phase was separated and washed with water, 5% hydrochloric acid, water, 5% NaOH solution, and again with water. After drying over magnesium sulfate, the solution was evaporated to dryness.