تفاعل #816383

معادلة التفاعل

pMDI

bromocriptine

bromocriptine mesylate

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Bromocriptine

ظروف التفاعل

المعالجة

1. 1
   أخرىfitted with a USP induction port (<USP 601> Pharmacopeial Previews 22, 3065 (1995))
2. 2
   ترشيحfilter
3. 3
   أخرىwere actuated per test, with an interval of at least 30 seconds between shots
4. 4
   درجة الحرارةto prevent cooling of the can
5. 5
   أخرىresultant moisture condensation
6. 6
   ترشيحfilter (corresponding to particles of MMAD less than 3.3 μm)

الإجراء التجريبي

The formulations were tested on an Andersen™ cascade impactor to determine their aerodynamic particle properties. The cascade impactor was operated at 28.3 I/min and fitted with a USP induction port (<USP 601> Pharmacopeial Previews 22, 3065 (1995)). The particle size distributions were fractionated into mass of drug deposited on the pMDI actuator, USP induction port, eight stages and terminal filter. Five shots were actuated per test, with an interval of at least 30 seconds between shots to prevent cooling of the can and resultant moisture condensation. The bromocriptine content in each sample was determined by HPLC. The percentage of the total dose deposited from stage 4 to the terminal filter (corresponding to particles of MMAD less than 3.3 μm) was considered to be the fine particle fraction.

المصدر