تفاعل #81617

معادلة التفاعل

4-(4-chloro-1-oxobutyl)-2,2-dimethylphenethyl acetate

α,α-diphenyl-4-piperidinemethanol

potassium hydrogen carbonate

potassium iodide

→

4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-2,2-dimethylphenethyl acetate

المذيبات

water

toluene

water

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 72 hours
2. 2
   ترشيحFilter
3. 3
   ترشيحthrough filter aid while at 80° C.
4. 4
   أخرىseparate the organic phase
5. 5
   تجفيفDry (MgSO4)
6. 6
   ترشيحfilter
7. 7
   أخرىpurify by chromatography (ethyl acetate)

الإجراء التجريبي

Mix 4-(4-chloro-1-oxobutyl)-2,2-dimethylphenethyl acetate (99.5 g, 0.335 mol), α,α-diphenyl-4-piperidinemethanol (101.8 g, 0.335 mol), potassium hydrogen carbonate (83.8 g, 0.838 mol), potassium iodide (1.00 g, 0.006 mol), toluene (600 mL) and water (220 mL). Stir at reflux for 72 hours, add toluene (200 mL) and deionized water (100 mL). Filter through filter aid while at 80° C. and separate the organic phase. Dry (MgSO4), filter and purify by chromatography (ethyl acetate) to give 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-2,2-dimethylphenethyl acetate as an oily solid.

المصدر