تفاعل #81616

معادلة التفاعل

2,2-dimethylphenethyl acetate

aluminum chloride

→

title compound

4-(4-Chloro-1-oxobutyl)-2,2-dimethylphenethyl acetate

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةPlace under a nitrogen atmosphere, cool to 0°-5° C.
2. 2
   أخرىat approximately 0° C
3. 3
   أخرىquench
4. 4
   workup.ADDITIONby slowly pouring over approximately 2L of crushed ice
5. 5
   workup.STIRRINGAdd methylene chloride (500 mL) and stir for 5 minutes
6. 6
   أخرىSeparate the organic phase
7. 7
   استخلاصextract the aqueous phase with methylene chloride (300 mL)
8. 8
   غسيلCombine the organic phases and wash with saturated aqueous sodium hydrogen carbonate (3×200 mL), with deionized water (200 mL) and brine (200 mL)
9. 9
   تجفيفDry (MgSO4)
10. 10
    workup.STIRRINGstir for 30 minutes
11. 11
    ترشيحbefore filtering
12. 12
    أخرىEvaporate the solvent in vacuo
13. 13
    أخرىpurify by chromatography (ethyl acetate/hexane)

الإجراء التجريبي

Charge a flask with aluminum chloride (223 g, 1.68 mol) and methylene chloride (200 mL). Place under a nitrogen atmosphere, cool to 0°-5° C. and add, by dropwise addition, ω-chlorobutyryl chloride (188.6 g, 1.34 mol). After acid chloride addition is complete, add, by dropwise addition, 2,2-dimethylphenethyl acetate (128.0 g, 0.67 mol ), keeping the temperature at approximately 0° C. Continue stirring at 0° C. for 2 hours, quench by slowly pouring over approximately 2L of crushed ice. Add methylene chloride (500 mL) and stir for 5 minutes. Separate the organic phase and extract the aqueous phase with methylene chloride (300 mL). Combine the organic phases and wash with saturated aqueous sodium hydrogen carbonate (3×200 mL), with deionized water (200 mL) and brine (200 mL). Dry (MgSO4) and stir for 30 minutes before filtering. Evaporate the solvent in vacuo and purify by chromatography (ethyl acetate/hexane) to give the title compound as an orange/brown oil.

المصدر