تفاعل #81611

معادلة التفاعل

ethyl 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoate

sodium hydroxide

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title compound

المردود 82.6%

3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoic acid

المردود 82.6%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 1 hour
3. 3
   أخرىevaporated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in a small volume of water
5. 5
   استخلاصThe resulting mixture was extracted several times with ether
6. 6
   تجفيفthe combined extracts were dried (MgSO4)
7. 7
   أخرىevaporated

الإجراء التجريبي

A mixture of ethyl 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoate (500 mg), 2N sodium hydroxide solution (1.5 ml) and methanol (5 ml) was heated under reflux for 1 hour and then evaporated. The residue was dissolved in a small volume of water, and the solution was made acidic with 2N hydrochloric acid. The resulting mixture was extracted several times with ether and the combined extracts were dried (MgSO4) and evaporated to give the title compound,(390 mg), m.p. 85°-87° C. Found: C,60.78A H,5.06; N,2.87. C24H33ClFNO4S requires C,60.56; H,4.87; N,2.94%.

المصدر