تفاعل #815588

معادلة التفاعل

2-nitro-4-carboxyaniline

heptadecanol

dimethylaminopyridine

→

2-Nitro-4-(heptadecyloxycarbonyl)aniline

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىwas prepared
2. 2
   ترشيحfiltered
3. 3
   أخرىAfter separating between chloroform and 3% caustic soda solution the organic phase
4. 4
   غسيلwas washed with water
5. 5
   تجفيفdried with magnesium sulphate
6. 6
   أخرىthe solvent removed
7. 7
   أخرىto leave a yellow solid
8. 8
   أخرىThe solid was purified by chromatography
9. 9
   أخرىto give a yellow solid which
10. 10
    أخرىwas recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.)

الإجراء التجريبي

A mixture of 2-nitro-4-carboxyaniline (0.52 g), heptadecanol (0.7 g) and dimethylaminopyridine (20 mg) in dichloromethane (20 ml) was prepared and dicyclohexyldicarbodiimide (0.62 g) was added. The mixture was stirred for 48 hours and filtered. After separating between chloroform and 3% caustic soda solution the organic phase was washed with water, dried with magnesium sulphate and the solvent removed to leave a yellow solid. The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.).

المصدر