تفاعل #8154

معادلة التفاعل

m-nitrophenylhydrazine hydrochloride

2-acetyl-3-oxo-butyric acid ethyl ester

pyridine

→

3,5-dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىA precipitate was formed in the reaction medium
2. 2
   ترشيحwas collected by filtration
3. 3
   أخرىsynthesis of the named product
4. 4
   أخرىm.p., 107.7° C.–109.2° C.

الإجراء التجريبي

Similar to Example 1, m-nitrophenylhydrazine hydrochloride (10 mmol, 1.9 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a 50% solution of pyridine in ethanol. A precipitate was formed in the reaction medium, and was collected by filtration. Analysis confirmed synthesis of the named product, m.p., 107.7° C.–109.2° C.

المصدر