تفاعل #81520

معادلة التفاعل

4-Piperidine methanol

N,N-diisopropylethylamine

N-(2-bromoethyl)methanesulphonamide

→

title compound

المردود 54.8%

N-[2-[4-(Hydroxymethyl)-1-piperidinyl]ethyl]methanesulphonamide

المردود 54.8%

المذيبات

acetonitrile

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture heated
2. 2
   درجة الحرارةat reflux for 2 h
3. 3
   أخرىThe solvent was removed in vacuo
4. 4
   أخرىto leave a gum
5. 5
   أخرىThis was purified by FCC
6. 6
   غسيلeluting with System A (75:8:1)

الإجراء التجريبي

4-Piperidine methanol (1.60 g) was dissolved in dry acetonitrile (40 ml), N,N-diisopropylethylamine (5 ml) was added, followed by N-(2-bromoethyl)methanesulphonamide (2.95 g) in acetonitrile (10 ml), and the resulting mixture heated at reflux for 2 h. The solvent was removed in vacuo to leave a gum. This was purified by FCC eluting with System A (75:8:1) to give the title compound (1.80 g) as a solid, m.p. 81°-82°.

المصدر