تفاعل #81495

معادلة التفاعل

ethylene oxide

2-fluoro-6-methylpyridine

THF

LDA

→

2-fluoro-6-(3-hydroxypropyl)pyridine

المردود 30.9%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto warm to room temperature
2. 2
   workup.STIRRINGwith stirring
3. 3
   استخلاصextracted with ether
4. 4
   غسيلthe organic layer was washed with water (2x) and brine
5. 5
   تجفيفdried over sodium sulfate
6. 6
   تركيزThe organic solution was concentrated
7. 7
   أخرىthe residue was purified by flash chromatography (chloroform/ethanol, 10:1)

الإجراء التجريبي

To a solution of 2-fluoro-6-methylpyridine (27 mmol) in 65 ml of freshly distilled THF was added via syringe 13.5 ml of 2M LDA, and the resulting mixture was stirred at -78° C. for 20 min. To the above cold solution was added 4 ml of 4M ethylene oxide and the mixture was allowed to warm to room temperature with stirring. The mixture was diluted with water, extracted with ether, and the organic layer was washed with water (2x) and brine, and dried over sodium sulfate. The organic solution was concentrated, and the residue was purified by flash chromatography (chloroform/ethanol, 10:1) to yield 1.3 g (30.9%) of 2-fluoro-6-(3-hydroxypropyl)pyridine, as a yellow oil.

المصدر