تفاعل #81452

معادلة التفاعل

compound

5-benzyl-3,3-dibromo-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

acetic acid

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title product

المردود 60.0%

5-benzoyl-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

المردود 60.0%

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrate to dryness under reduced pressure
2. 2
   استخلاصextract with dichloromethane
3. 3
   أخرىThe crude product obtained
4. 4
   تركيزby concentrating to dryness
5. 5
   أخرىis purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4)

الإجراء التجريبي

Add a spatula tip of zinc to a solution of 40 mg of the compound of Step 2 in acetic acid. After 30 minutes' stirring, concentrate to dryness under reduced pressure, take up in water and extract with dichloromethane. The crude product obtained by concentrating to dryness is purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4). The title product is obtained in the form of an oil in a yield of 60%. ##STR63##

المصدر