تفاعل #81396

معادلة التفاعل

water

(S)-N-acetyl-cysteine

1-fluoro-2-nitrobenzene

sodium bicarbonate

→

product

المردود 84.1%

S-(o-Nitrophenyl)-N-acetyl-D-cysteine

المردود 84.1%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent evaporated
2. 2
   workup.DISSOLUTIONThe residue was dissolved in 136 mL of water
3. 3
   استخلاصextracted with ether
4. 4
   ترشيحThe resulting yellow precipitate was filtered

الإجراء التجريبي

A mixture of 9.28 g (56.9 mmol) of (S)-N-acetyl-cysteine, 7.43 mL (70.5 mmol) of 1-fluoro-2-nitrobenzene and 13.66 g (163 mmol) of sodium bicarbonate was refluxed in 136 mL of ethanol and 41 mL of water for 3 hours. The mixture was cooled to room temperature and the solvent evaporated. The residue was dissolved in 136 mL of water and extracted with ether. The water solution was then acidified to pH=1with 12N hydrochloric acid (HCl). The resulting yellow precipitate was filtered to yield 13.6 g (84%) of product.

المصدر