تفاعل #813859

معادلة التفاعل

HCl

1,2-dihydro-4-(3,4-methylenedioxyphenyl)-2-oxo-3-quinoline carboxylic acid ethyl ester

methanol

potassium hydroxide

→

title compound

المردود 95.4%

1,2-dihydro-4-(3,4-methylenedioxyphenyl)-2-oxo-3-quinoline carboxylic acid

المردود 95.4%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed
2. 2
   درجة الحرارةwith heat for 40 hours
3. 3
   أخرىto obtain a precipitated crystal
4. 4
   ترشيحby filtration
5. 5
   أخرىThe crystal obtained
6. 6
   غسيلwas washed with diethylether

الإجراء التجريبي

A mixture of 1,2-dihydro-4-(3,4-methylenedioxyphenyl)-2-oxo-3-quinoline carboxylic acid ethyl ester (40 g, 118.6 mmol), methanol (200 ml), water (300 ml) and potassium hydroxide (33.3 g, 593.5 mmol) was refluxed with heat for 40 hours. To the reaction mixture was added 110 ml of 6N-HCl to acidify the mixture to obtain a precipitated crystal by filtration. The crystal obtained was washed with diethylether to give 35 g (yield: 95.4%) of the title compound.

المصدر