تفاعل #81377

معادلة التفاعل

4-formylphenol

1-bromooctane

potassium carbonate

→

desired compound

4-octyloxybenzaldehyde

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight
2. 2
   أخرىthe reaction was quenched by the addition of 100 ml of water
3. 3
   استخلاصThe desired compound was extracted from the reaction mixture
4. 4
   تجفيفThe resultant solution was dried over magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuo
7. 7
   أخرىto provide a liquid which
8. 8
   أخرىwas purified

الإجراء التجريبي

A solution containing 3.053 g (25 mmol) of 4-formylphenol, 6.48 ml (3705 mmol) of 1-bromooctane and 6.9 mg (50 mmol) of potassium carbonate in 100 ml of acetone was refluxed overnight. When the reaction was substantially complete, as indicated by thin layer chromatagraphy (TLC), the reaction was quenched by the addition of 100 ml of water. The desired compound was extracted from the reaction mixture using two 100 ml portions of diethyl ether. The resultant solution was dried over magnesium sulfate, filtered and then concentrated in vacuo to provide a liquid which was purified using HPLC (eluent of 10 ethyl acetate in hexane) to provide the desired compound.

المصدر