تفاعل #81324

معادلة التفاعل

N-bromosuccinimide

benzoyl peroxide

diethyl 1-benzyl-2-methylimidazole-4,5-dicarboxylate

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title compound

المردود 74.9%

Diethyl 1-benzyl-2-bromomethylimidazole-4,5-dicarboxylate

المردود 74.9%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   غسيلAt the end of this time, the reaction solution was washed with a 5% w/v aqueous solution of sodium thiosulfate and with a saturated aqueous solution of sodium hydrogencarbonate, in that order
2. 2
   تركيزafter which it was concentrated by evaporation under reduced pressure
3. 3
   أخرىThe resulting residue was purified by column chromatography through silica gel
4. 4
   workup.ADDITIONby volume mixture of hexane and ethyl acetate as the eluent

الإجراء التجريبي

2.52 g of N-bromosuccinimide and 0.42 of benzoyl peroxide were added to a solution of 4.07 g of diethyl 1-benzyl-2-methylimidazole-4,5-dicarboxylate [prepared as described in step (i) above] in 80 ml of carbon tetrachloride, and the mixture was irradiated by a 375 W tungsten lamp for 50 minutes, whilst stirring. At the end of this time, the reaction solution was washed with a 5% w/v aqueous solution of sodium thiosulfate and with a saturated aqueous solution of sodium hydrogencarbonate, in that order, after which it was concentrated by evaporation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 3:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 3.81 g of the title compound as a syrup.

المصدر