تفاعل #813058

معادلة التفاعل

(2RS,4SR,5RS)-1-{2-[3-(3-(benzyloxycarbonylmethyl)phenyl)ureido]acetyl}-5-(2-fluorophenyl)-2-(1,2,3,4-tetrahydro-1-quinolylcarbonyl)-4-(phenylsulphonyl)pyrrolidine

→

(2RS,4RS,5SR)-3-{3-[2-(5-(2-fluorophenyl)-2-(1,2,3,4-tetrahydro-1-quinolylcarbonyl)-4-(phenylsulphonyl)-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid

المردود 66.6%

المذيبات

ethanol

ظروف التفاعل

الإجراء التجريبي

A The reaction is carried out in a way analogous to that described in Example 2A, but from 2.83 g of (2RS,4SR,5RS)-1-{2-[3-(3-(benzyloxycarbonylmethyl)phenyl)ureido]acetyl}-5-(2-fluorophenyl)-2-(1,2,3,4-tetrahydro-1-quinolylcarbonyl)-4-(phenylsulphonyl)pyrrolidine and 0.36 g of 10% palladium-on-charcoal in 150 cm3 of ethanol. After treatment, there are obtained 1.67 g of (2RS,4RS,5SR)-3-{3-[2-(5-(2-fluorophenyl)-2-(1,2,3,4-tetrahydro-1-quinolylcarbonyl)-4-(phenylsulphonyl)-1-pyrrolidinyl)-2-oxoethyl]ureido}phenylacetic acid [Rf =0.49; eluent: methylene chloride/methanol (90/10)].

المصدر