تفاعل #81181

معادلة التفاعل

pivaloyloxymethyl-1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

hydrogen chloride

→

title compound

المردود 109.1%

Pivaloyloxymethyl 1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

المردود 109.1%

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
2. 2
   أخرىthe residue was triturated with ethyl acetate
3. 3
   أخرىto crystallize it

الإجراء التجريبي

A mixture of 6.6 g of pivaloyloxymethyl-1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate [prepared as described in step (c) above] and 57 ml of a 4N solution of hydrogen chloride in dioxane was stirred at room temperature for 4 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the residue was triturated with ethyl acetate to crystallize it, giving 6.52 g of the title compound as the hydrochloride, melting at 170°-173° C.

المصدر