تفاعل #81165

معادلة التفاعل

4-benzoyl-2-butyl-5-cyanoimidazole

t-butyl 4'-bromomethylbiphenyl-2-carboxylate

potassium carbonate

→

title compound

المردود 80.7%

4-Benzoyl-1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-5-cyanoimidazole

المردود 80.7%

المذيبات

N,N-dimethylacetamide

ظروف التفاعل

المعالجة

1. 1
   أخرىpurifying the product by column chromatography through silica gel
2. 2
   workup.ADDITIONby volume mixture of hexane and ethyl acetate as the eluent

الإجراء التجريبي

Following a procedure similar to that described in Example 11(a), but using 1.27 g of 4-benzoyl-2-butyl-5-cyanoimidazole (prepared as described in Preparation 6), 1.74 g of t-butyl 4'-bromomethylbiphenyl-2-carboxylate, 0.69 of potassium carbonate and 20 ml of N,N-dimethylacetamide, and then purifying the product by column chromatography through silica gel, using a 2:1 by volume mixture of hexane and ethyl acetate as the eluent, 2.1 g of the title compound were obtained.

المصدر