تفاعل #81111
ord-f0ac4d596dbe41c58ce781b429bc5435
معادلة التفاعل
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الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةThe reaction mixture was warmed at 50° C. for 5 hours
- 2درجة الحرارةre-cooled to -20° C.
- 3درجة الحرارةThe reaction mixture was heated an additional 2.5 hours at 50° C.
- 4تركيزconcentrated under reduced pressure
- 5أخرىto afford an amorphous solid
- 6أخرىThe solid was triturated with ether
الإجراء التجريبي
To anhydrous methanol (15 mL) at -20° C. under nitrogen was added thionyl chloride (4 mL) dropwise. The solution was allowed to warm to room temperature and then tert-Leucine (4.00 g) was added. The reaction mixture was warmed at 50° C. for 5 hours, re-cooled to -20° C. and then additional thionyl chloride (3 mL) was added dropwise. The reaction mixture was heated an additional 2.5 hours at 50° C. and then concentrated under reduced pressure and chased twice with methanol (15 mL) to afford an amorphous solid. The solid was triturated with ether to afford the title compound in 92% yield. The 300 MHz 1H NMR spectrum was found to be consistent with the proposed structure. MS (DCI/NH3) m/e 146 (M+H)+.