تفاعل #81073

ord-1b0b73807bcb47e7ad054cd94bc82b55

معادلة التفاعل

CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1
3,5-di-t-butylbenzoic acid
O=[N+]([O-])O
nitric acid
O=S(Cl)Cl
thionyl chloride
→
CC(C)(C)c1cc(C(=O)Cl)c([N+](=O)[O-])c(C(C)(C)C)c1
3,5-Di-t-butyl-2-nitrobenzoyl chloride
CC(C)(C)c1cc(C(=O)O)c([N+](=O)[O-])c(C(C)(C)C)c1
3,5-di-t-butyl-2-nitrobenzoic acid

المتفاعلات

CC(C)(C)c1cc(C(=O)O)cc(C(C)(C)C)c1
3,5-di-t-butylbenzoic acid
O=[N+]([O-])O
nitric acid
O=S(Cl)Cl
thionyl chloride

الكواشف

لا شيء

المذيبات

CN(C)C=O
dimethylformamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

3,5-Di-t-butyl-2-nitrobenzoyl chloride was prepared by nitration of 3,5-di-t-butylbenzoic acid 46.86 grams (0.20 mol) with 90% nitric acid (150 ml, d=1.5) to give 3,5-di-t-butyl-2-nitrobenzoic acid (54.6 grams) followedby treatment with thionyl chloride (250 ml) with dimethylformamide (1 ml).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05616797uspto-grants-1997_04