تفاعل #80983

معادلة التفاعل

4-(chloromethyl)-2-isopropylthiazole hydrochloride

cyclopropylamine

→

desired compound

المردود 19.0%

2-Isopropyl-4-(((N-cyclopropyl)amino)methyl)thiazole

المردود 19.0%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   أخرىpurified by silica gel chromatography

الإجراء التجريبي

A solution of 1.8 g (10.2 mmol) of 4-(chloromethyl)-2-isopropylthiazole hydrochloride in 10 ml of chloroform was added dropwise with stirring to 10 ml of cyclopropylamine. The resulting solution was stirred at ambient temperature for 16 h, concentrated in vacuo, and purified by silica gel chromatography using 5% methanol in chloroform to provide 0.39 g (19%) of the desired compound. 1H NMR (DMSO-d6) δ0.24 (m, 2H), 0.35 (m, 2H),1.30 (d, J=7 Hz, 6H), 2.10 (tt, J=12, 3 Hz, 1H), 3.23 (heptet, J=7 Hz, 1H), 3.77 (s, 2H), 7.21 (s, 1H). Mass spectrum: (M+H)+ =197.

المصدر