تفاعل #80967

معادلة التفاعل

2-methylpropane-thioamide

1,3-dichloroacetone

MgSO4

→

crude desired compound

4-(Chloromethyl)-2-isopropylthiazole hydrochloride

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 3.5 h
3. 3
   درجة الحرارةto cool
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent was removed in vacuo

الإجراء التجريبي

A mixture of 94.0 g (0.91 mol) of 2-methylpropane-thioamide, 115.7 g (0.91 mol) of 1,3-dichloroacetone, and 109.7 g (0.91 mol) of MgSO4 in 1.6 liters of acetone was heated at reflux for 3.5 h. The resulting mixture was allowed to cool, filtered, and the solvent was removed in vacuo to provide the crude desired compound as a yellow oil. 1H NMR (DMSO-d6) δ1.32 (d, J=7 Hz, 6H), 3.27 (heptet, J=7 Hz, 1H), 4.78 (s, 2H), 7.61 (s, 1H). Mass spectrum: (M+H)+ =176.

المصدر