تفاعل #809229

معادلة التفاعل

benzene sulfonyl chloride

2-[2-(4-methoxypyridin-2-yl)ethyl]-6-(4-aminophenyl)-3H-imidazo[4,5-b]pyridine

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title compound

N-(4-{2-[2-(4-Methoxypyridin-2-yl)ethyl]-3H-imidazo[4,5-b]pyridin-6-yl}phenyl)-benzenesulfonamide

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent is evaporated in vacuo
2. 2
   أخرىthe residue is is chromatographed on a silica gel column (dichloromethane/methanol 30–20:1+1% triethylamine)
3. 3
   أخرىConcentration of the chromatographically pure fractions and drying

الإجراء التجريبي

0.047 ml of benzene sulfonyl chloride are added to 0.115 g of 2-[2-(4-methoxypyridin-2-yl)ethyl]-6-(4-aminophenyl)-3H-imidazo[4,5-b]pyridine (example 27) in 1 ml of pyridine and the mixture is stirred at ambient temperature for three hours. The solvent is evaporated in vacuo and the residue is is chromatographed on a silica gel column (dichloromethane/methanol 30–20:1+1% triethylamine). Concentration of the chromatographically pure fractions and drying gives 0.093 g of the title compound as a solid of m.p. 251–253° C. The mass spectrum shows the molecular peak MH+ at 486.3 Da.

المصدر