تفاعل #80894

معادلة التفاعل

2,4,6-triaminoquinazoline

hydrochloric acid

sodium nitrite

potassium cyanide

→

2,4-diamino-6-cyanoquinazoline

المذيبات

water

ظروف التفاعل

الإجراء التجريبي

The 2,4,6-triaminoquinazoline derivatives described above may then optionally be treated with 2N hydrochloric acid, sodium nitrite, potassium cyanide, and copper(II) sulfate pentahydrate in water, affording the corresponding 2,4-diamino-6-cyanoquinazoline, for example, 2,4-diamino-6-cyano-5-methylquinazoline. Step A of Example 14 describes in detail this step in the reaction sequence.

المصدر