تفاعل #8089

معادلة التفاعل

sodium hydrogencarbonate

4-methoxycarbonyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one

potassium carbonate

isobutyl bromide

→

title compound

المردود 65.1%

4-carboxy-2-isobutyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one

المردود 65.1%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىto drop back to room temperature
2. 2
   استخلاصThe mixture was then extracted with ethyl acetate
3. 3
   غسيلThe extract was washed with brine
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off
6. 6
   أخرىthe residue was reacted

الإجراء التجريبي

To a solution of 4-methoxycarbonyl-6-[4-(methylthio)-phenyl]-2H-pyridazin-3-one (8.00 g, 29.0 mmol) in N,N-dimethylformamide (80 mL) were added potassium carbonate (8.02 g, 58.0 mmol) and isobutyl bromide (4.76 g, 34.8 mmol), and the mixture was stirred at 80° C. for 2 hours. The temperature of the reaction mixture was allowed to drop back to room temperature, and a saturated aqueous solution of sodium hydrogencarbonate was added. The mixture was then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was distilled off. Following the procedure of Example 1 (7), the residue was reacted to yield the title compound as a yellow solid [yield: 65.1% (2 steps)].

المصدر