تفاعل #80557

معادلة التفاعل

NaCNBH3

(R)-3-amino-8-fluoro-5-methoxy-3,4-dihydro-2H-1-benzopyran

cyclopentanone

HOAc

→

title compound

(R)-3-(N-Cyclopentylamino)-8-fluoro-5-methoxy-3,4dihydro-2H-1-benzopyran

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONadded in portions at room temperature

الإجراء التجريبي

To a solution of (R)-3-amino-8-fluoro-5-methoxy-3,4-dihydro-2H-1-benzopyran (2.5 g, 12 mmol), cyclopentanone (3.3 g, 36 mmol) and HOAc (0.7 g, 12 mmol) in methanol (25 mL ) was NaCNBH3 (2.5 g, 40 mmol) added in portions at room temperature. The solution was stirred at room temperature overnight to give a quantitative yield of the title compound. GC/MS (70 eV) M=265 (30%).

المصدر