تفاعل #80427

معادلة التفاعل

2-((3-Methyl-4-(2-benzylaminoethylthio)pyridin-2-yl)methylthio)-1H-benzimidazole

methyl chloroacetate

potassium carbonate

→

2-((3-methyl-4-(2-(N-benzyl-N-methoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the completion of the reaction
2. 2
   workup.DISTILLATIONthe dimethylformamide was distilled away
3. 3
   استخلاصthe residue was extracted with ethyl acetate
4. 4
   تجفيفThe ethyl acetate layer was dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled away
6. 6
   أخرىto give an oily product
7. 7
   أخرىThe oily product was purified by column chromatography

الإجراء التجريبي

2-((3-Methyl-4-(2-benzylaminoethylthio)pyridin-2-yl)methylthio)-1H-benzimidazole (2 g) was dissolved in dimethylformamide and reacted with methyl chloroacetate (0.45 ml) in the presence of potassium carbonate (0.71 g) at 50°-60° C. After the completion of the reaction, the dimethylformamide was distilled away and the residue was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and the solvent was distilled away to give an oily product. The oily product was purified by column chromatography to give 2-((3-methyl-4-(2-(N-benzyl-N-methoxycarbonylmethylamino)ethylthio)-2-pyridyl)methylthio)-1H-benzimidazole.

المصدر