تفاعل #80327

معادلة التفاعل

N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide

2-mercaptoethanol

→

title compound

المردود 66.0%

N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-hydroxyethylthio)butyramide

المردود 66.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction at 80° C. for 5 hours

الإجراء التجريبي

Following a procedure similar to that described in Example 1, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercaptoethanol as starting materials, in relative proportions similar to those used in that Example, and carrying out the reaction at 80° C. for 5 hours, the title compound was obtained in a 66% yield.

المصدر