تفاعل #80320

معادلة التفاعل

6-hydroxy-4-(3'-methylanilino)quinazoline

1,2-dibromoethane

→

6-(2-bromoethoxy)-4-(3'-methylanilino)quinazoline

المردود 47.0%

المذيبات

DMA

ظروف التفاعل

الإجراء التجريبي

Using an analogous procedure to that described in Example 39, except that DMA was used in place of DMF and that the reaction mixture was heated to 80° C. for 4 hours, 6-hydroxy-4-(3'-methylanilino)quinazoline was reacted with 1,2-dibromoethane to give 6-(2-bromoethoxy)-4-(3'-methylanilino)quinazoline in 47% yield, m.p. 129°-135° C.

المصدر