تفاعل #80295

معادلة التفاعل

benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

→

desired compound

المردود 97.0%

1-Benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylic Acid

المردود 97.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحInsoluble matters were filtered off
2. 2
   تركيزfiltrate was concentrated under reduced pressure
3. 3
   أخرىThe residue thereby obtained
4. 4
   غسيلwas washed with isopropyl ether

الإجراء التجريبي

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

المصدر