تفاعل #80270

معادلة التفاعل

N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine

phenyl chloroacetate

→

N-2-((Phenoxycarbonyl)oxy)ethyl-N-((phenoxycarbonyl)methyl)-N,N-dimethyl-ammonium Chloride

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer
2. 2
   workup.ADDITIONinternal thermometer, addition funnel, and argon inlet
3. 3
   workup.ADDITIONAfter addition
4. 4
   درجة الحرارةthe mixture is heated
5. 5
   درجة الحرارةto reflux for 3 h
6. 6
   أخرىThe cooled mixture is triturated with ether (500 ml)
7. 7
   أخرىA white solid, 23.15 g (51%) is isolated
8. 8
   أخرىto give 9

الإجراء التجريبي

To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer, internal thermometer, addition funnel, and argon inlet are added N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine (25.00 g, 0.120 mol), acetonitrile (100 ml), and phenyl chloroacetate (20.38 g, 0.120 mol) over 5 min. After addition is complete, the mixture is heated to reflux for 3 h. The cooled mixture is triturated with ether (500 ml). A white solid, 23.15 g (51%) is isolated to give 9.

المصدر