تفاعل #80259

معادلة التفاعل

hydrogen peroxide

isatin

sulfuric acid

→

isatoic acid anhydride

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere charged in a 500 ml two-neck flask
2. 2
   workup.STIRRINGthe mixture was stirred at 60° to 65° C. for one hour
3. 3
   درجة الحرارةa half and then cooled
4. 4
   ترشيحThe deposit was filtered
5. 5
   غسيلwashed with water
6. 6
   أخرىdried under vacuum

الإجراء التجريبي

The isatin derivative (70 g) obtained in the above item (i), 200 ml of acetic acid and 0.8 ml of concentrated sulfuric acid were charged in a 500 ml two-neck flask and the mixture was stirred at room temperature. Then, 50 ml of 30% hydrogen peroxide was added dropwise to the mixture. After the completion of dropping, the mixture was stirred at 60° to 65° C. for one hour and a half and then cooled. The deposit was filtered, washed with water and dried under vacuum to give 35 g of a derivative of isatoic acid anhydride represented by the following formula (20): ##STR24##

المصدر