تفاعل #80258

معادلة التفاعل

chloral

hydroxylammonium chloride

hydrochloride

aniline

isatin

→

isonitrosoacetanilide

ظروف التفاعل

المعالجة

1. 1
   أخرىas shown in the following reaction scheme
2. 2
   أخرىan aqueous solution obtained
3. 3
   أخرىis reacted for 0.5 to 2 hours
4. 4
   درجة الحرارةwith heating at 70° to 110° C.

الإجراء التجريبي

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

المصدر