تفاعل #80183

معادلة التفاعل

4′-Trifluoromethyl-biphenyl-2-carboxylic acid

thionyl chloride

→

title product

المردود 99.0%

4′-Trifluoromethyl-biphenyl-2-carbonyl chloride

المردود 99.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةat reflux
3. 3
   تركيزthe mixture was concentrated under vacuum

الإجراء التجريبي

4′-Trifluoromethyl-biphenyl-2-carboxylic acid (25 g, 94 mmol) was combined with thionyl chloride (35 ml, 470 mmol) and the mixture was heated at reflux. After 2 h, the mixture was concentrated under vacuum to afford 26.5 g of the title product as a light yellow oil.

المصدر