تفاعل #8006

معادلة التفاعل

sodium hydroxide

ethyl 2-ethoxycarbonyl-4-(3-fluoro-4-methylphenyl)-2-hydroxy-4-oxobutanoate

hydrazine monohydrate

hydrochloric acid

→

title compound

4-carboxy-6-(3-fluoro-4-methylphenyl)-2H-pyridazin-3-one

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   workup.STIRRINGthe mixture was stirred further at the same temperature for 4 hours
3. 3
   درجة الحرارةcooled
4. 4
   ترشيحThe precipitate was collected by filtration
5. 5
   غسيلthoroughly washed with water
6. 6
   أخرىdried

الإجراء التجريبي

To a solution of ethyl 2-ethoxycarbonyl-4-(3-fluoro-4-methylphenyl)-2-hydroxy-4-oxobutanoate (8.41 9, 25.8 mmol) in isopropanol (100 mL) was added hydrazine monohydrate (2.84 g, 56.8 mmol), and the mixture was heated under stirring at 100 for 6 hours. Then, 2 mol/L sodium hydroxide was added, and the mixture was stirred further at the same temperature for 4 hours. The reaction mixture was ice-cooled, and concentrated hydrochloric acid was added to acidify the system. The precipitate was collected by filtration, thoroughly washed with water and dried to yield the title compound as a slightly yellow crystalline powder (5.67 g, 87.7%).

المصدر