تفاعل #799094

معادلة التفاعل

(±)-trans-2-(methoxymethyl)cyclopropylboronic acid

2-amino-6-bromobenzonitrile

→

(±)-trans-2-amino-6-(2-(methoxymethyl)cyclopropyl)benzonitrile

المردود 64.0%

ظروف التفاعل

الإجراء التجريبي

Prepared as in Example 270a from (±)-trans-2-(methoxymethyl)cyclopropylboronic acid (example 271b) and 2-amino-6-bromobenzonitrile in 64% yield as a yellowish brown waxy solid. 1H NMR (400 MHz, DMSO-d6) δ 0.932 (m, 2H), 1.341 (m, 1H), 1.879 (m, 1H), 2.324 (s, 3H), 3.351 (d, J=6 Hz, 2H), 5.896 (br. s, 2H), 6.148 (d, J=8 Hz, 1H), 6.550 (d, J=8 Hz, 1H), 7.130 (t, J=8 Hz, 1H).

المصدر