تفاعل #79904

معادلة التفاعل

2-fluoro-4-iodo-benzyl bromide

Intermediate 1

2-fluoro-4-iodo-benzyl bromide

water

sodium cyanide

→

title compound

المردود 96.4%

2-Fluoro-4-iodo-phenyl acetonitrile

المردود 96.4%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 0.5 h
2. 2
   workup.DISTILLATIONThe volatiles were distilled off in vacuo
3. 3
   workup.ADDITIONthe residue was diluted with water
4. 4
   استخلاصextracted with diethyl ether (×2)
5. 5
   استخلاصThe combined organic extract
6. 6
   غسيلwas washed with water (×1) and brine (×1)
7. 7
   تجفيفdried over anhydrous magnesium sulfate
8. 8
   ترشيحfiltered
9. 9
   أخرىevaporated in vacuo

الإجراء التجريبي

A solution of 2-fluoro-4-iodo-benzyl bromide (Intermediate 1, 2.56 g, 8.15 mmol) in ethanol (55 mL and water (10 mL) was treated with sodium cyanide (2.15 g, 43.86 mmol) and refluxed for 0.5 h. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with diethyl ether (×2). The combined organic extract was washed with water (×1) and brine (×1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as a pale yellow solid (2.05 g, 96%).

المصدر