تفاعل #79855

معادلة التفاعل

Hypersil

2-(3-chloro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

trans-4-chloro-5-iodo-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidine

trans-5-{4-amino-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-phenoxybenzonitrile

→

title compound

trans-5-(3-Chloro-4-phenoxyphenyl)-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىtr 15.75 min.

الإجراء التجريبي

The title compound was prepared from 2-(3-chloro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and trans-4-chloro-5-iodo-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidine in a similar manner to that described for the preparation of trans-5-{4-amino-7-[4-(4-methylpiperazino)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-phenoxybenzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 8.14 (s, 1H), 7.79(s, 1H), 7.65 (s, 1H), 7.38(m, 3H), 7.16(t, 2H), 7.04 (d, 2H), 6.24(bs, 2H), 4.55(m, 1H), 2.2-2.6(m, 9H), 2.16(s, 3H), 1.89(m, 6H), 1.48 (m, 2H); MS MH+517.3; RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 15.75 min.

المصدر