تفاعل #79763

معادلة التفاعل

2-fluorobenzonitrile

4-bromophenol

potassium carbonate

→

2-(4-bromophenoxy)benzonitrile

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   workup.WAITto stand overnight at ambient temperature
3. 3
   أخرىpartitioned between ethyl acetate and water
4. 4
   أخرىThe organic layer was separated
5. 5
   غسيلwashed
6. 6
   أخرىdried
7. 7
   أخرىevaporated
8. 8
   أخرىto give an oil which
9. 9
   أخرىThe solid was triturated with petroleum ether b.p. 40-60° C.
10. 10
    ترشيحfiltered

الإجراء التجريبي

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

المصدر