تفاعل #79761

معادلة التفاعل

4-iodophenol

2-fluorobenzaldehyde

potassium carbonate

→

2-(4-iodophenoxy) benzaldehyde

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled to ambient temperature
2. 2
   ترشيحfiltered
3. 3
   workup.ADDITIONWater (500 ml) was added to the filtrate
4. 4
   استخلاصthe mixture was extracted with ethyl acetate
5. 5
   أخرىto give a solid which
6. 6
   أخرىwas triturated with hot hexane (500 ml)
7. 7
   أخرىThe supernatant liquid was decanted from a residual gum
8. 8
   درجة الحرارةcooled
9. 9
   أخرىThe solid which precipitated
10. 10
    ترشيحwas collected by filtration

الإجراء التجريبي

A mixture of 4-iodophenol (25.0 g), 2-fluorobenzaldehyde (14.14 g), potassium carbonate (31.5 g) and dimethylformamide (500 ml) was heated at 120° C. under nitrogen with stirring for 15 hours. The mixture was cooled to ambient temperature and filtered. Water (500 ml) was added to the filtrate and the mixture was extracted with ethyl acetate to give a solid which was triturated with hot hexane (500 ml). The supernatant liquid was decanted from a residual gum and cooled. The solid which precipitated was collected by filtration to give 2-(4-iodophenoxy) benzaldehyde, m.p. 84.5-86° C.

المصدر