تفاعل #79723

معادلة التفاعل

2-chloro-4-fluoro-5-nitroanisole

→

2-fluoro-5-methoxyaniline

المذيبات

ethanol

triethylamine

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىthe solvent was evaporated
3. 3
   ترشيحfiltered thourough a plug of silica gel
4. 4
   أخرىevaporated

الإجراء التجريبي

A solution of 5.63 g of 2-chloro-4-fluoro-5-nitroanisole in 90 ml of ethanol and 5 ml of triethylamine was hydrogenated at room temperature under 60 pounds per square inch with 1.0 g of 5% palladium on carbon for four hours. The catalyst was filtered off and the solvent was evaporated. The residue was slurried in chloroform and filtered thourough a plug of silica gel and then evaporated.

المصدر