تفاعل #79722

معادلة التفاعل

(2-chloro-4-fluoro-5-nitrophenyl)-ethyl carbonate

cesium carbonate

iodomethane

methanol

→

subtitle compound

المردود 97.1%

2-chloro-4-fluoro-5-nitroanisole

المردود 97.1%

المذيبات

water

dimethyl formamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted twice with ether
2. 2
   غسيلThe extracts were washed twice with water
3. 3
   تجفيفwith brine, dried over magnesium sulfate
4. 4
   تركيزconcentrated

الإجراء التجريبي

A solution of 15.0 g of (2-chloro-4-fluoro-5-nitrophenyl)-ethyl carbonate in 100 ml of dimethyl formamide was treated with 18.6 g of cesium carbonate, 7.1 ml of iodomethane and 7 ml of methanol and stirred overnight at room temperature. The reaction mixture was poured into water and extracted twice with ether. The extracts were washed twice with water and then with brine, dried over magnesium sulfate and concentrated to afford 11.4 g of the subtitle compound. mp. 69-70° C. Ex. 57, C.

المصدر