تفاعل #796863

معادلة التفاعل

methyl acrylate

1-(benzyloxy)-3-bromo-5-fluorobenzene

triphenylphosphine

triethylamine

→

methyl 3-(3-(benzyloxy)-5-fluorophenyl)acrylate

المذيبات

acetonitrile

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere further added
2. 2
   أخرىthe solvent was evaporated under reduced pressure

الإجراء التجريبي

To a solution of 1-(benzyloxy)-3-bromo-5-fluorobenzene (6.60 g) in acetonitrile (130 mL) were added methyl acrylate (13.7 g), triphenylphosphine (3.36 g) and triethylamine (14.5 g), and toluene (2.0 mL) and palladium acetate (480 mg) were further added. The reaction mixture was stirred at 100° C. for 96 hr, and the solvent was evaporated under reduced pressure.

المصدر