تفاعل #79569

معادلة التفاعل

N-cyclohexylaniline

benzyl isothiocyanate

→

(cyclohexylphenylamino)-N-benzylthiocarboxamide

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   أخرىthe residue purified on preparative silica gel plates

الإجراء التجريبي

To a solution of N-cyclohexylaniline (0.1 ml, 0.57 mmol) in acetonitrile (4 ml) was added a catalytic amount of 4-(dimethylamino)pyridine (5 mg, 0.04 mmol). To this mixture was added benzyl isothiocyanate (0.11 ml, 0.83 mmol) dropwise, and the mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on preparative silica gel plates, developing with 20% ethyl acetate/hexanes, to furnish (cyclohexylphenylamino)-N-benzylthiocarboxamide as a white solid, (M+1)=324.8.

المصدر