تفاعل #79547

معادلة التفاعل

4-(2,3-Dimethoxybenzoyl)pyridine

4-(2,3-dimethoxybenzoyl)pyridine

→

4-[1-Hydroxy-1-(2,3-dimethoxyphenyl)methyl]piperidine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAt the conclusion of the reaction
2. 2
   أخرىthe catalyst was removed by filtration
3. 3
   غسيلThe reactor and catalyst cake were washed with methanol

الإجراء التجريبي

4-(2,3-Dimethoxybenzoyl)pyridine (12) (10.09 g, 42 mmol) was dissolved in 100 mL of methanol and hydrogenated using a 5% rhodium on carbon catalyst. At the conclusion of the reaction, the catalyst was removed by filtration. The filtrate weighed 113.90 g. The reactor and catalyst cake were washed with methanol. The combined washes weighed 165.26 g.

المصدر