تفاعل #79546

معادلة التفاعل

4-(2,3-dimethoxybenzoyl)pyridine

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title compound ( 11 )

المردود 92.5%

4-[1-Hydroxy-1-(2,3-dimethoxyphenyl)methyl]piperidine

المردود 92.5%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration through Celite7
2. 2
   ترشيحfilter aid
3. 3
   تركيزthe filtrate is concentrated at reduced pressure

الإجراء التجريبي

A solution of 4-(2,3-dimethoxybenzoyl)pyridine (12) (2.10 g, 8.6 mmol) in MeOH (10 mL) is treated with 5% Rh/alumina (0.72 g). The mixture is hydrogenated in a Parr shaker at 55 psig for 22 hours. After filtration through Celite7 filter aid, the filtrate is concentrated at reduced pressure to give the title compound (11) as a solid (2.0 g, 92% yield).

المصدر